Details of Element: Sample 1
Component of Clamp

Unique Name: sam1q29
Contained in the Common BLSA Data Set ? Yes

Data Points (as of 09/06/98) Males Females Total
Number of Data Points 453 3 456
Number of Distinct Participants 307 3 310
Year First Collected 1972 1979 -
Year Last Collected 1981 1980 -

Type of Variable: Absolute Measure
Encoding: Continuous
Units of Measure: mg/dL
Precision: ###.
Anticipated Range: 000. thru 999.
Masterfile Index: 128-02-01
Related Data Elements: sam1q , sam1q3 , sam1q7 , sam1q11 , sam1q18 , sam1q21 , sam1q25 , sam1q26 , sam1q32 , sam1q36 , sam1q45
Specific to this Data Element:
    Descriptive history:
    The 128 file type contains data from the fasting sample obtained prior to administration of a hyperglycemic or hyperinsulinemic-euglycemic clamp procedure. Data from this test has been collected in BLSA men from 1972 to 1981.

    Data collection methodology:
    Blood chemistry.

    Related protocols:
    Other blood chemistries.

    Investigators:
    Dr. Reubin Andres (primary investigator)
    GRC Box-24
    andresr@grc.nia.nih.gov
    (410)-558-8194

    Frequency of data collection:
    Data were collected in selected BLSA men from 1972 to 1981.

    Inclusion/exclusion rules:
    No exclusions.

    Publications using these data:

  • Andres, R., Swerdloff, R., Tobin, J. The effect of age on plasma insulin response to hyperglycemia: Studies in man with a servo-control technique. Proceedings 8th International Congress of Gerontology; 1969:36-39.
  • Andres, R., Swerdloff, R., Pozefsky, T., Coleman, D. Manual feedback technique for the control of blood glucose concentration. In: Skeegs LJ, ed. Automation in Analytical Chemistry. New York: Mediad, Inc.; 1966:486-491.
  • Andres, R., Langs, H., Pozefsky, T., Swerdloff, R., Gregerman, R. Alterations in carbohydrate metabolism with age: quantification and investigation into the underlying mechanisms. Proceedings 7th International Congress of Gerontology. Vienna, Austria: Verlag der Weiner Medizinischen Akademie; 1966:351-353.
  • Andres, R. Aging and diabetes. Med Clin North Am. 55(4): 835-46,1971.
  • Andres, R., Tobin, J. Aging, carbohydrate metabolism, and diabetes. Proceedings 9th International Congress of Gerontology; 1972:276-280.
  • Andres, R. Aging and carbohydrate metabolism. In: Carlson L, ed. Nutrition in Old Age. Symposia of the Swedish Nutrition Foundation. Sweden: Almqvist and Wiksell; 1972:24-31.
  • DeFronzo, R.A., Andres, R., Edgar, P., Walker, W.G. Carbohydrate metabolism in uremia: a review. Medicine. 52(5): 469-81,1973.
  • Insel, P.A., Kramer, K.J., Sherwin, R.S., Liljenquist, J.E., Tobin, J.D., Andres, R., Berman, M. Modeling the insulin-glucose system in man. Fed Proc. 33(7): 1865-8,1974.
  • Sherwin, R.S., Kramer, K.J., Tobin, J.D., Insel, P.A., Liljenquist, J.E., Berman, M., Andres, R. A model of the kinetics of insulin in man. J Clin Invest. 53(5): 1481-92,1974.
  • Insel, P., Lilijenquist, J., JD, T., Sherwin, R., Watkins, P., Andres, R., Berman, M. Insulin control of glucose metabolism in man: A new kinetic analysis. J. Clin. Invest. 55: 1057-1066,1975.
  • Tobin, J., Andres, R. The control of insulin and glucose metabolism in aging man. Proceedings 10th International Congress of Gerontology; 1975:183-185.
  • Andres, R., Tobin, J.D. Aging and the disposition of glucose. Adv Exp Med Biol. 61: 239-49,1975.
  • McGuire, E.A., Helderman, J.H., Tobin, J.D., Andres, R., Berman, M. Effects of arterial versus venous sampling on analysis of glucose kinetics in man. J Appl Physiol. 41(4): 565-73,1976.
  • DeFronzo, R.A., Andres, R., Bedsoe, T.A., Boden, G., Faloona, G.A., Tobin, J.D. A test of the hypothesis that the rate of fall in glucose concentration triggers counterregulatory hormonal responses in man. Diabetes. 26(5): 445-52,1977.
  • Andres, R., Tobin, J. Endocrine systems. In: Finch C, Hayflick L, eds. Handbook of the Biology of Aging. New York: Van Nostrand Reinhold Co.; 1977:357-378.
  • Vestal, R.E., McGuire, E.A., Tobin, J.D., Andres, R., Norris, A.H., Mezey, E. Aging and ethanol metabolism. Clin Pharmacol Ther. 21(3): 343-54,1977.
  • DeFronzo, R.A., Tobin, J.D., Rowe, J.W., Andres, R. Glucose intolerance in uremia. Quantification of pancreatic beta cell sensitivity to glucose and tissue sensitivity to insulin. J Clin Invest. 62(2): 425-35,1978.
  • Andersen, D.K., Elahi, D., Brown, J.C., Tobin, J.D., Andres, R. Oral glucose augmentation of insulin secretion. Interactions of gastric inhibitory polypeptide with ambient glucose and insulin levels. J Clin Invest. 62(1): 152-61,1978.
  • DeFronzo, R.A., Tobin, J.D., Andres, R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 237(3): E214-23,1979.
  • Elahi, D., Andersen, D.K., Brown, J.C., Debas, H.T., Hershcopf, R.J., Raizes, G.S., Tobin, J.D., Andres, R. Pancreatic alpha- and beta-cell responses to GIP infusion in normal man. Am J Physiol. 237(2): E185-91,1979.
  • McGuire, E.A., Tobin, J.D., Berman, M., Andres, R. Kinetics of native insulin in diabetic, obese, and aged men. Diabetes. 28(2): 110-20,1979.
  • Elahi, D., Andersen, D.K., Tobin, J.D., Andres, R. Discrepant performance on oral and intravenous glucose tolerance tests: the role of gastric inhibitory polypeptide. J Clin Endocrinol Metab. 52(6): 1199-203,1981.
  • Andres, R. Aging, diabetes, and obesity: standards of normality. Mt Sinai J Med. 48(6): 489-95,1981.
  • Elahi, D., Nagulesparan, M., Hershcopf, R.J., Muller, D.C., Tobin, J.D., Blix, P.M., Rubenstein, A.H., Unger, R.H., Andres, R. Feedback inhibition of insulin secretion by insulin: relation to the hyperinsulinemia of obesity. N Engl J Med. 306(20): 1196-202,1982.
  • Elahi, D., Raizes, G.S., Andres, R., Hershcopf, R.J., Muller, D.C., Tobin, J.D., Andersen, D.K. Interaction of arginine and gastric inhibitory polypeptide on insulin release in man. Am J Physiol. 242(5): E343-51,1982.
  • Helderman, J.H., Elahi, D., Andersen, D.K., Raizes, G.S., Tobin, J.D., Shocken, D., Andres, R. Prevention of the glucose intolerance of thiazide diuretics by maintenance of body potassium. Diabetes. 32(2): 106-11,1983.
  • Elahi, D., Andersen, D.K., Muller, D.C., Tobin, J.D., Brown, J.C., Andres, R. The enteric enhancement of glucose-stimulated insulin release. The role of GIP in aging, obesity, and non-insulin-dependent diabetes mellitus. Diabetes. 33(10): 950-7,1984.
Details for this Data Type
JM - Disclaimer

Revised 09/18/98 -- Send comments to our Web Master .